DelveInsight, a leading market research and consulting firm, has recently published an in-depth report on the Toll-like Receptor Agonists pipeline, providing valuable insights into emerging therapies, companies, and future outlooks.
DelveInsight’s, “Toll-Like Receptor Agonist Pipeline Insight 2023” report provides comprehensive insights about 60+ companies and 60+ pipeline drugs in Toll-Like Receptor Agonist pipeline landscape. It covers the Toll-like Receptor Agonists pipeline drug profiles, including Toll-like Receptor Agonists’ clinical trials and nonclinical stage products. It also covers the Toll-like Receptor Agonists therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
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Key Takeaways from the Toll-like Receptor Agonists Pipeline Report
For further information, refer to the detailed Toll-like Receptor Agonists Unmet Needs, Toll-like Receptor Agonists Market Drivers, and Toll-like Receptor Agonists Market Barriers, click here for Toll-like Receptor Agonists Ongoing Clinical Trial Analysis
Toll-like Receptor Agonists Overview
Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first line of defense against invading microbes. TLR1, -2, -4, -5, -6, and -10 are expressed on the cell surface, whereas TLR3, -7, -8, and -9 are situated on endosomal membranes within the cell [5, 9, 10]. TLR1 and TLR2 can heterodimerize to recognize a variety of bacterial lipid structures and cell wall components, such as triacylated lipoproteins, lipoteichoic acid, and β-glucans.
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Toll-like Receptor Agonists Emerging Drugs Profile
Cobitolimod is a first-in-class Toll-like receptor 9 (TLR9) agonist that can provide an anti-inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis. Cobitolimod met the primary endpoint in the Phase IIb study CONDUCT and demonstrated an outstanding combination of efficacy and safety. In March 2021, InDex Pharmaceuticals announced that the company has entered an agreement for services with global clinical research organization (CRO) Parexel Biotech for the Phase III study CONCLUDE. The study will evaluate the efficacy and safety of the drug candidate cobitolimod for the treatment of moderate to severe left-sided ulcerative colitis.
Tilsotolimod is an investigational, synthetic Toll-like receptor 9 agonist. Intratumoral injection of tilsotolimod has been shown to promote both innate (Type-I IFN, antigen presentation) and adaptive (T cells) immune activation. Tilsotolimod has received both Fast Track designation and Orphan Drug designation from the FDA and is being evaluated in multiple tumor types and in combination with multiple checkpoint inhibitors. In March 2021, Idera Pharmaceuticals announced that ILLUMINATE-301, the Company’s pivotal registration trial of tilsotolimod in combination with ipilimumab versus ipilimumab alone in patients with anti-PD-1 refractory advanced melanoma, did not meet its primary endpoint of objective response rate (ORR).
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Toll-like Receptor Agonists Pipeline Therapeutics Assessment
There are approx. 60+ key companies which are developing the therapies for Toll- Like Receptor Agonist. The companies which have their Toll- Like Receptor Agonist drug candidates in the most advanced stage, i.e. Phase III include, InDex Pharmaceuticals.
Scope of the Toll-like Receptor Agonists Pipeline Report
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